The latest MLS predictions and best betting tips for the weekend’s matches, including Montreal vs Austin and LA Galaxy vs Colorado Rapids.

Luis Suarez scored twice on penalty kicks and Inter Miami overcame Lionel Messi’s absence to beat Tigres UANL from Mexico, 2-1, in a Leagues Cup quarterfinal Wednesday (Thursday in Manila).

Lionel Messi, who returned from injury last weekend, suffered a setback and had to miss the Leagues Cup quarterfinal against Tigres.

The 2025 Leagues Cup quarterfinals delivered drama and goals, setting up an all-MLS semifinal stage for the first time in the tournament’s history, leaving Liga MX out of the final stretch.

Inter Miami faces a setback as Jordi Alba is forced off injured in their Leagues Cup quarterfinal, joining Lionel Messi on the sidelines.

The Galaxy are struggling through a miserable MLS, but they continued to shine Leagues Cup play with a 2-1 win over Mexican power Pachuca Wednesday.

Manager Javier Mascherano's assistant, Javier Morales, spoke to the media and revealed why Lionel Messi was left out of the Leagues Cup game.