Abstract. EGFR-TKIs like osimertinib are widely used to treat advanced EGFR-mutant NSCLC, however tumors inevitably acquire resistance. Amplification of MET occurs in ~20% of EGFR-TKI resistant tumors ...
Cancer Research | 85 | 8_Supplement_1 | April 2025 Journal Archive Cancer Research (1941-Present; volumes 1-current) Published twice monthly since 1987. From 1941-1986, published monthly. (ISSN ...
From molecules to medicine, from proteomics to prevention, the journals of the AACR cover the entire spectrum of cancer research. Please select the journal that is most appropriate for your manuscript ...
Abstract. The overexpression of HER3 in solid tumors is associated with poor prognosis. Therapies developed to target HER3-mediated signaling are often associated with resistance over time, ...
Abstract. The regulation of epithelial (E) and mesenchymal (M) states requires orchestrated adaptation at the epigenomic level. The 3D genome hierarchical orders, together with chromatin accessibility ...
NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale—within the United States—of Bavencio (avelumab), a ...
Marilyn Hammer, Robin Lally, Barbara Halpenny, Hajime Uno, Ijeoma Eche-Ugwu, Whitney Posada, Inga Van Wieren, Alexi Wright, Ayodeji Adeniji, Sarah Alzahid, Lauren A ...
AbstractBackground:. Urothelial carcinoma (UC) affects over 600,000 patients worldwide annually, with the incidence rate increasing over the past decade. Metastatic urothelial carcinoma (mUC) has a ...
Abstract. Regulatory T cells (Tregs) have long been appreciated as a key suppressive cell type that limits anti-tumor immunity, yet it has been challenging to find an effective approach to target this ...
AbstractBackground:. Colorectal cancer is highly heterogeneous, exhibiting diverse tumor characteristics. However, studies focusing on the epithelial cell compartment remain limited. Here, we aimed to ...
1Center for Immune-Related Diseases at Shanghai Institute of Immunology, State Key Laboratory of Systems Medicine for Cancer, Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong ...
Developing drugs against multi-protein complexes is traditionally challenging. In this study, we develop molecular COUPLrs, dual cysteine-reactive small molecules, that can engage complexes across the ...
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