JAK enzymes are part of the JAK/STAT pathway. This signaling pathway transmits chemical signals from the outside of cells, specifically lymphocytes, and into the cell nucleus.

Jul 15, 2025 · Janus kinase (JAK) inhibitors are a group of medicines that help block immune system signals in the body that can lead to swelling (inflammation) and pain in conditions like rheumatoid …

Aug 23, 2025 · In this article, learn about the dosage, uses, and ongoing research underway for JAK inhibitors available in the United States, as well as common side effects, contraindications, and …

Recently, Janus kinase inhibitors (JAKi) have been developed to block the effect of proinflammatory cytokines in IMIDs.

Jul 28, 2025 · The JAK-signal transducer and activator of transcription (STAT) pathway is central to immune dysregulation in many autoimmune diseases due to its role in transducing signals from an …

Aug 2, 2025 · Janus Kinase inhibitors are employed in the management of various medical conditions, primarily those involving immune system dysregulation and chronic inflammation. This class of drugs …

Jan 5, 2026 · The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway mediates cellular responses to cytokines and growth factors, and its dysregulation plays a role in …

Jun 2, 2024 · Jason Hawkes, MD, MS, medical dermatologist in Sacramento, California presented an in-depth overview on the mechanism of action (MOA) of Janus Kinase (JAK) inhibitors, a class of small …

Discover how JAK inhibitors work, their benefits for autoimmune conditions like rheumatoid arthritis, potential side effects, and precautions to consider before starting treatment.

JAK-STAT signaling pathway The JAK-STAT signaling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death, and tumor …